6-Chloropyridine-3-boronic acid pinacol ester

6-Chloropyridine-3-boronic acid pinacol ester - Names and Identifiers

Name	2-Chloro-5-pyridylboronic acid pinacol ester
Synonyms	AKOS BRN-0198 RARECHEM AK ML 0445 2-Chloropyridine-5-boronicacidpinacolester 2-CHLORO-5-PYRIDYLBORONIC ACID PINACOL ESTER 2-Chloro-5-pyridylboronic acid pinacol ester 6-CHLOROPYRIDINE-3-BORONIC ACID PINACOL ESTER 6-Chloropyridine-3-boronic acid pinacol ester 2-CHLORO-5-PYRIDINEBORONIC ACID PINACOL ESTER 6-CHLOROPYRIDIN-3-YLBORONIC ACID PINACOL ESTER 2-CHLOROPYRIDINE-5-BORONIC ACID, PINACOL ESTER 2-CHLORO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxabaorolan-2-yl)pyridine
CAS	444120-94-9
InChI	InChI=1/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3

6-Chloropyridine-3-boronic acid pinacol ester - Physico-chemical Properties

Molecular Formula	C11H15BClNO2
Molar Mass	239.51
Density	1.14±0.1 g/cm3(Predicted)
Melting Point	86-90°C
Boling Point	328.3±27.0 °C(Predicted)
Flash Point	152.4°C
Vapor Presure	0.000364mmHg at 25°C
pKa	0.17±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.505
MDL	MFCD03412793

6-Chloropyridine-3-boronic acid pinacol ester - Risk and Safety

Risk Codes	R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	29333990
Hazard Class	IRRITANT

6-Chloropyridine-3-boronic acid pinacol ester - Introduction

2-Chloro-5-pyridylboronic acid pinacol ester is an organic compound with the chemical formula C11H15BClNO2. It is a solid, usually in the form of white crystals.

The compound is widely used in organic synthesis. It is an important reagent for the esterification of alcohols and can be used for the synthesis of various boron-containing compounds. In addition, it can also be used as an organic nucleophile to participate in various reactions such as phenyl substitution reactions and condensation reactions.

the preparation of 2-Chloro-5-pyridylboronic acid pinacol ester is usually obtained by reacting boric acid with 2-chloro-5-pyridylmethanol. The reaction conditions are generally at room temperature, and dimethyl sulfoxide (DMSO) is usually used as a solvent, and stirring is required during the reaction.

Regarding safety information, 2-Chloro-5-pyridylboronic acid pinacol ester is generally safe in routine operation, but it is still necessary to pay attention to some routine laboratory safety. During use, contact with skin, eyes and respiratory tract should be avoided. At the same time, maintain good ventilation and wear appropriate personal protective equipment, such as laboratory gloves and goggles. In the event of accidental exposure to the compound, rinse immediately with plenty of water and seek medical attention if necessary.

Last Update：2024-04-10 22:29:15